FAQ

Frequently Asked Questions

FAQ

Frequently Asked Questions

Order, Shipping and Tracking

When purchasing on a subscription plan you can save 15%. The subscription can be paused or canceled at any time. Ongoing orders are $41.95 when on a subscription plan. We also offer single pack orders at $49.95.

PreCardix® is a safe and effective supplement for cardiovascular health. PreCardix® contains unique bioactive marine peptides that have been studied in peer-reviewed clinical trials for its effect on blood pressure health. The clinical documentation was prepared by a third party clinical research organization (CRO) in accordance with clinical research standards governed by ethics review committees and process in Europe and North America.

PreCardix® is the result of over a decade of research and multi-million dollar investment conducted in partnership between the University of Tromso Norway and the R&D Institute Norfima and Marealis Health Inc. PreCardix®’s unique refined shrimp peptide concentrate (Marealis RSPC) is derived from the proteins of fresh, cold water Arctic shrimps (Pandalus Borealis) through a controlled enzymatic hydrolysis process. Enzymatic hydrolysis breaks down larger protein chains into smaller, peptide chains. These peptide chains are further refined into Marealis RSPC through a proprietary process resulting in a clinically proven bioactive peptide with an ACE inhibiting action.

Our current pricing supports on-going quality and future R&D.

PreCardix® is a safe and effective supplement cardiovascular health. Some insurance companies offer coverage for supplements. You are welcome to check with your insurance provider to see if this is something they offer.

Your order will ship within 1-2 business days either by Amazon FBA or our USA Warehouse. Delivery time varies by destination. Once your order is shipped out, transit time within the continental United States is normally between 2-5 days, depending on your location. Shipping outside of the continental United States may take approximately 3-7 days, depending on your location.

Subscriptions are sent automatically each month.

Once your order is shipped, you will receive an email with tracking information. If for some reason you don’t receive it, please contact us at support@precardix.com and our customer support team will be happy to provide you with that information and help answer any other questions you might have.

You can safely pay for your Single Order or Subscription through our safe payment processing platforms. If purchasing a Subscription, your credit card will be billed monthly. Your (monthly) order will be shipped 1-2 working days after the billing date. If, for any reason you would like to cancel your subscription, please contact us at support@precardix.ca one week before your billing date or manage your subscription from My account. Your billing date will be clearly noted on your order confirmation form. Please save this information for future reference. If you cancel your order after your billing date, please allow up to one week for a refund to appear on your credit card.

When purchasing a single order of PreCardix®, you will get an account. When purchasing a subscription to PreCardix®, you will also automatically get an account. To access your account go to this link: https://precardix.com/my-account/

You are able to reset your password on our website precardix.com. Go to ‘my account’, and then under the ‘login’ section you can click on ‘forgot my password’, follow the steps and you should then receive an email to the account listed on your profile where you can reset your password. If you need any assistance, please contact us at support@precardix.com.

PreCardix® is available online and Amazon.com

PreCardix® does not require a prescription.

PreCardix® is a safe and effective supplement for cardiovascular health.

Side Effects and Contraindications

PreCardix® is not appropriate for or during:

  • Pregnancy or while breast-feeding
  • Children under 18 years old
  • Individuals with a shellfish allergy
  • Patients who have a history of angioedema related to the use of ACEI medication
  • Patients with renal artery stenosis

Patients who are on medications or who have pre-existing health conditions should always consult with their health care provider before initiating PreCardix®. Never stop or change your medication without consulting with your health care provider. PreCardix® is not a substitute for medication.

PreCardix® does not have any known serious side effects. It has not been found to cause side effects sometimes associated with ACE inhibitor medication such as dry cough, itching, edema (swelling), high potassium levels, or hypotension (low blood pressure).

PreCardix® may cause moderate nausea and/or stomach discomfort. One case of mild euphoric mood, fatigue, upper abdominal pain, and headache occurred during the clinical trial.

Clinical research has not found any cases of hypotension when taking PreCardix®. There are also no documented cases of hypotension from our customers currently using PreCardix® either.

There are some important factors to consider in consultation with your health care provider:

1. PreCardix® was taken as directed – 2 tablets together daily before noon away from food, medication and other supplements for at least eight weeks.

2. Blood pressure at eight weeks was compared to baseline blood pressure before introducing PreCardix®.

3. Baseline blood pressure was established by measuring blood pressure two times each morning and evening for one week before introducing PreCardix®.

4. Blood pressure at eight weeks was established by measuring blood pressure for one week two times each morning and evening, eight weeks after  introducing PreCardix®.

5. Lifestyle factors such as diet, exercise, stress, and other habits have not changed negatively.

The frequency at which you measure your blood pressure is essential, and so is how  you measure it. Check out this blog for simple steps for taking your BP at home to ensure your readings are accurate and reliableRemember to always use a Hypertension Canada-approved blood pressure device for the most accurate readings.

It is essential to monitor your blood pressure regularly and accurately. Always share your blood pressure readings with your health care provider to discuss options, and to ensure your blood pressure management plan is effective and safe to continue.

We are happy to provide a full refund for up to two months of product (2 x 60 tablets). Please contact us at support@precardix.com for your refund options.

PreCardix® has not been found to increase potassium levels. In the clinical trial, serum potassium levels were measured at baseline and at 8 weeks in all study participants. There was no clinically significant difference between potassium levels at both baseline and at 8 weeks between the placebo and treatment group. However, considering PreCardix® bioactive marine peptides’ ACE-inhibiting action, caution should be taken when using PreCardix® with agents that increase serum potassium such as potassium-sparing diuretics, potassium supplements, and potassium-containing salts. Individuals using any of these combinations should have serum potassium levels monitored frequently.

Share the PreCardix® product monograph with your health care provider who can advise you on drug interactions, contra-indications and other factors related to your health to help determine if PreCardix® is appropriate for you.

PreCardix® should not be used in patients with known shellfish allergies. The active ACE-inhibiting peptides in PreCardix® are derived from the shells of arctic cold-water shrimp.

PreCardix® has not been studied in pregnancy or breastfeeding and should be avoided throughout the entire gestational period due to the potential teratogen effects of ACE inhibitors. Women who are breastfeeding should not take PreCardix®.

Children under the age of 18 should not take PreCardix®.

Always consult with your health care provider before making any changes to your blood pressure management plan.
PreCardix® does not treat, cure or prevent medical conditions. Measure and monitor blood pressure regularly. Know the signs of heart attack and stroke. Do not take PreCardix® if you are pregnant, breastfeeding, have renal artery stenosis, history of angioneurotic edema or shellfish allergy.

Research and Efficacy

PreCardix® is the result of over a decade of research and development dedicated to finding an effective, sustainable, and proven natural product to support blood pressure health.

Clinical research found that the unique bioactive marine peptides derived from hydrolyzed shrimp shells (Pandalus Borealis) found in PreCardix® have an ACE inhibiting action. The use of bioactive marine peptides in clinical trials resulted in an effect blood pressure health in over 89% of participants within eight weeks or less.

PreCardix®’s bioactive marine peptide study scale documented mechanism of action, and patented peptide formula differentiate PreCardix® from other peptide formulas on the market.

Yes, we have conducted two clinical studies, Mare-study (preliminary clinical trial) and Marealis 13TBHM (peer-reviewed, double-blind, placebo-controlled, multicenter clinical trial). These studies were conducted on the bioactive marine peptides (RSPC) in PreCardix® between 2012 and 2015 on over two hundred and twenty male and female participants aged 30 – 75.

Clinical research found that the unique bioactive marine peptides derived from hydrolyzed shrimp shells (Pandalus Borealis) found in PreCardix® have an ACE inhibiting action. The use of bioactive marine peptides in clinical trials resulted in a statistically significant effect on blood pressure health in over 89% of participants within eight weeks or less.

Read the entire clinical trial published in the International Journal of Hypertension here.

Participants in the PreCardix® bioactive marine peptides clinical trial were unmedicated, healthy males and females with mild-moderately elevated baseline blood pressure (blood pressure <160/100 mmHg), aged 30-75.

To better control for other variables, only untreated, healthy participants with no other pre-existing conditions / co-morbities were included in the clinical trial. This is very common in well-designed clinical trials.

Participants in the PreCardix® bioactive marine peptides clinical trial were healthy males and females with mild-moderate baseline blood pressure (blood pressure < 160/100 mmHg) aged 30-75. The average baseline office systolic blood pressure of study participants was 147-149 mmHg.

Participants in the PreCardix® bioactive marine peptides clinical trial were unmedicated, healthy males and females with mild-moderately elevated baseline blood pressure (blood pressure <160/100 mmHg) aged 30-75.

In the clinical trial, 89% of participants experienced a significant effect on their blood pressure health within eight weeks without significant side effects. Compared to baseline blood pressure, the average reduction in systolic blood pressure was 6.7 mmHg, and 1.7 mmHg in diastolic blood pressure within 8 weeks¹. 43% of participants had a systolic blood pressure improvement over 10 mmHg, and 24% improved over 15 mmHg in systolic blood pressure.

To learn more about what to expect when you start taking PreCardix®, and for best results, please visit us here.

¹ Musa-Veloso K, Paulionis L, Pelipyagina T, Evans M. A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure. Int J Hypertens. 2019;2019:2345042. Published 2019 Aug 5. doi:10.1155/2019/2345042. Ref. table 4.

Health Canada approves PreCardix® as a safe and effective natural product for healthy blood pressure and cardiovascular health. The Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA) also approve PreCardix®. PreCardix® is an innovation of Marealis Health, a certified B Corporation.

PreCardix® is the result of over a decade of extensive research, product development, and clinical trials, demonstrating product safety and a statistically significant effect on blood pressure health. PreCardix® is a registered Natural Health Product (NPN) 80080580. You can find PreCardix on Health Canada’s NPN database here. Multiple safety and efficacy studies were performed on people in Canada, the US, Czech Republic, Germany, and Finland, documenting the product’s significant effect on blood pressure health. No serious side effects were associated with PreCardix® during the studies. You can read more about the clinical trials here . Always consult with your health care provider before making changes to your blood pressure management plan.

Yes! All PreCardix® customer stories and testimonials are regular PreCardix® customers. Our online reviews are verified by a third-party, and Amazon.com reviews follow their stringent review guidelines. You can read our growing library of customer stories here.

Our clinical studies show that after one month 58% of adults taking PreCardix® experienced a significant effect on their blood pressure health, while after two months (8 weeks) 89% experienced a significant effect on their blood pressure, compared to baseline. This shows that for some people it may take some time before they are able to experience an effect on their blood pressure health. This is why we always advise our new customers to try PreCardix® for at least 8 weeks before being able to conclude on its effectiveness. Also, be sure to take as directed: 2 tablets together, a few hours before or after taking other medications or natural health products or food, before noon. Allow 2-8 weeks to achieve results. Continue to take daily to maintain results.

To learn more about what to expect when you start taking PreCardix®, and for best results, visit us here.

We would love to learn more about your experience with PreCardix® and offer our support, please feel free to contact our customer support team at support@precardix.com.

Please note that we have a Money Back Guarantee: if for any reason you are not satisfied with your results after taking PreCardix® for at least 8 weeks,  we will provide a full refund for up to two months of product (2 x 60 tablets). The Money Back Guarantee program is available for purchases made at precardix.com (please make sure to keep your proof of purchase). Please email us at support@precardix.com for next steps.

There are five important factors to consider in consultation with your health care provider when determining the effectiveness of PreCardix®:

1. PreCardix® was taken as directed – 2 tablets together daily before noon away from food, medication and other supplements for at least eight weeks.

2. Blood pressure at eight weeks was compared to baseline blood pressure before introducing PreCardix®.

3. Baseline blood pressure was established by measuring blood pressure two times each morning and evening for one week before introducing PreCardix®.

4. Blood pressure at eight weeks was established by measuring blood pressure for one week two times each morning and evening, eight weeks after introducing PreCardix®.

5. Lifestyle factors such as diet, exercise, stress and other habits have not changed negatively.

If you have completed these five steps and have not experienced the desired effect on your blood pressure, please discuss options with your health care provider.  If you choose to discontinue PreCardix®, please contact us about our Money Back Guarantee program by emailing us at support@precardix.ca.  The Money Back Guarantee program is available for purchases made at precardix.com (please make sure to keep your proof of purchase).

Manufacturing Standards

PreCardix® bioactive marine peptides are derived from Norwegian coldwater shrimp, and locally sourced non-medicinal ingredients. PreCardix® is manufactured in North America.

Each tablet of PreCardix® contains 600 mg of protein hydrolysate from cold water shrimp (Pandalus borealis) shell. The active medicinal ingredient is Refined Shrimp Peptide Concentrate (RSPC) made up of peptides 2-7 amino acids long which pass unmodified into the bloodstream. These bioactive peptides work synergistically to produce ACE-inhibiting effects. Some peptides exert direct ACE-inhibition and two of the most potent constituents in PreCardix® have been patented. The non-medicinal ingredients required for tablet manufacturing and palatability are microcrystalline cellulose, croscarmellose sodium, magnesium stearate, silicon dioxide, polyethylene glycol, talc (less than 20mg of USP-NF talc in the tablet’s coating), polyvinyl alcohol, titanium dioxide.

PreCardix® is derived from the shells of cold-water Arctic shrimps (Pandalus Borealis). No other shellfish or species are used to produce PreCardix®.

PreCardix® contains a unique refined shrimp peptide concentrate (Marealis RSPC). This unique peptide concentrate is derived from the proteins of fresh, cold water Arctic shrimps (Pandalus Borealis) through a controlled enzymatic hydrolysis process. Enzymatic hydrolysis breaks down larger protein chains into smaller, peptide chains. These peptide chains are further refined into Marealis RSPC through a proprietary process resulting in bioactive marine peptide with an ACE inhibiting action.

Yes, the production process of PreCardix® is completely safe. There are no artificial substances added in the production process, and the production facilities are approved to the strictest standards in Norway and Canada. The product itself has also gone through extensive studies on animals and humans to prove its safety.

Yes, PreCardix®’s developing company Marealis AS is a Certified B Corporation. Certified B Corporations (B Corps) are businesses that meet the highest standard of social and environmental performance, public transparency, and legal accountability to balance profit and purpose. B Corps are crucial in facilitating and accelerating a global culture shift to redefine success in business and build a more inclusive and sustainable economy.

PreCardix® bioactive marine peptides are derived from the shells of sustainable cold water shrimps from the Arctic sea. These shrimp shells used to be considered waste. Pandalus Borealis (wild Arctic shrimps) are harvested by PreCardix®’s founder, Stella Polaris. Stella Polaris is one of the world’s leading producers of cold water shrimps. Stella Polaris is BRC (British Retail Consortium) and DNV certified. BRC is one of the world’s most demanding quality standards for food production. Stella Polaris is also MSC (Marine Stewardship Council) and KRAV certified. KRAV certified companies are dedicated to economically, organically, and socially sustainable food production without compromising the ability of future generations to meet their own needs.

PreCardix® is produced without genetic engineering or synthetic excipients, and it is made with non-GMO ingredients.

Yes, PreCardix® is gluten free.

No, PreCardix® is not vegan or vegetarian. The active ingredient, PreCardix® bioactive marine peptides are derived from the shells of sustainable cold water shrimps from the Arctic sea and therefore PreCardix® is not considered vegan or vegetarian. These shrimp shells used to be considered waste. Pandalus Borealis (wild Arctic shrimps) are harvested by PreCardix® founders, Stella Polaris. Stella Polaris is one of the world’s leading producers of cold water shrimps. Stella Polaris is BRC (British Retail Consortium) and DNV certified. BRC is one of the world’s most demanding quality standards for food production. Stella Polaris is also MSC (Marine Stewardship Council) and KRAV certified. KRAV certified companies are dedicated to economically, organically, and socially sustainable food production without compromising the ability of future generations to meet their own needs.

PreCardix® contains USP-NF Talc. The United States Pharmacopeial Convention, Incorporated, (USP) is a scientific nonprofit organization that sets standards for the identity, strength, quality, and purity of medicines, food ingredients, and dietary supplements manufactured, distributed, and consumed worldwide. USP Grade means a product meets all requirements in the USP monograph for that product and is manufactured in a cGMP compliant facility. NF Grade means a product meets all requirements in the NF monograph and is produced in a cGMP compliant facility. Each PreCardix® tablet contains less than 20mg (about twice the weight of a grain of table salt) of USP-NF talc which is used in the tablet’s coating. Customer concerns are related to the use of talc topically as in talcum powder or asbestos contamination. USP-NF talc does not contain asbestos, and it is safe to consume as a supplement ingredient. You can learn more about the requirements for USP-NF talc here. PreCardix® has been tested in multiple safety and efficacy studies internationally, and has been approved for sale by Health Canada, the FDA, and the European Food Safety Authority.

The iodine content of PreCardix® has been analyzed in a laboratory setting and determined to be 40.3mg/kg, or 0.048 mg of iodine in a daily dose of 2 tablets of PreCardix® (the amount of active ingredient per daily dose of PreCardix® is 1,200 mg of shrimp peptide concentrate).

For reference, the daily recommended intake of iodine for a healthy adult is 150mcg, or 0.15 mg. Therefore, each daily dose of PreCardix® fulfills approximately 1/3rd of the recommended daily intake of iodine in healthy adults. Please discuss with your health care provider if this is an appropriate level of iodine for you, especially if you have any underlying conditions or are taking any medications and/or supplements.

The shells of 1 kg of shrimp, when extracted and refined through our proprietary controlled enzymatic hydrolysis process, provide the active ingredient equaling approximately a 1-month dosage of PreCardix®. The shrimp proteins are refined through a proprietary enzymatic hydrolysis process to produce the ACE-inhibiting attributes associated with the peptides in the final product. Shells contain in-tact proteins and would not have the same effect on blood pressure.

None of the inactive ingredients in PreCardix® are derived from animal sources

Mechanism of Action

PreCardix® bioactive marine peptides have a clinically documented ACE inhibiting action. ACE inhibitors affect blood pressure by preventing ACE (angiotensin-converting enzyme) from converting angiotensin 1 to angiotensin 2. Angiotensin 2 increases blood pressure in several ways, including stimulating sodium and fluid retention and constricting blood vessels. Inhibiting excess levels of ACE reduces angiotensin 2.

PreCardix® bioactive marine peptides have a clinically documented ACE inhibiting action. ACE inhibitors affect blood pressure by preventing ACE (angiotensin-converting enzyme) from converting angiotensin 1 to angiotensin 2. Angiotensin 2 increases blood pressure in several ways, including stimulating sodium and fluid retention and constricting blood vessels. Inhibiting excess levels of ACE reduces angiotensin 2.

PreCardix® bioactive marine peptides have a clinically documented ACE inhibiting action. ACE inhibitors affect blood pressure by preventing ACE (angiotensin-converting enzyme) from converting angiotensin 1 to angiotensin 2. Clinical trials have shown that 89% of participants experienced a significant effect on their blood pressure health within 8 weeks or less. Therefore, we always advise people to try PreCardix® for at least 8 weeks before being able to determine if it works for you.

Take 2 tablets together daily before noon and away from other food, medications, or supplements. Allow 8 weeks to see results. Continue to take daily to maintain results.

PreCardix® is a unique composition of thousands of bioactive marine peptides derived from the shells of arctic cold-water shrimp. These short-chain peptides are isolated through a proprietary hydrolysis process. It is hypothesized by the PreCardix® research and development team that this unique combination of peptides mitigates the adverse effects seen with single-molecule ACE-inhibitors. It should be noted that this is a theory and further research on peptide-specific mechanisms of action is being conducted.

Unfortunately not. The bioactive marine peptides in PreCardix® are extracted through an extensive and patented production process where the natural proteins in the shrimp shells are broken down into smaller amino acid chains (peptides) through a controlled enzymatic hydrolysis process.

The enzymes added in the production process, splice the proteins into smaller fractions and thus create the extraordinary blood pressure health attributes. By consuming shrimps (or shrimp shells) in their natural form, you would be consuming the full length proteins. The body is not able to process the larger proteins into the smaller peptides found in the final PreCardix® tablet.

Therefore, these proteins won’t have the same effect on blood pressure health.

PreCardix® bioactive marine peptides are derived from sustainable cold water Arctic Shrimps (Pandalus Borealis) through a process called controlled enzymatic hydrolysis. This process breaks down shrimp proteins into smaller fragments called peptides. These proprietary PreCardix® peptides have been clinically proven to have a statistically significant effect on blood pressure health.

These peptides remain intact in the digestive system and enter the blood stream where they have an ACE inhibiting action. Further breakdown of these peptides occurs in the blood plasma, liver, and kidneys, and enzymatically where the peptides become amino acids, after the peptides have had the intended effect.

Blood Pressure Health

Hypertension is the medical term used to describe high blood pressure. Blood pressure is the force of the blood pumped from the heart against the blood vessels. This force makes blood flow possible, delivering nutrients and oxygen to organs and tissues throughout the body. Hypertension occurs when there is too much pressure in your blood vessels. This can damage your blood vessels and cause health problems. Anyone can develop high blood pressure, but it becomes more common as you get older.

The first step in understanding high blood pressure is learning what your numbers mean. Blood pressure is measured with two numbers: systolic (the higher number) and diastolic (the lower number) (e.g., 120/80 mmHg): Systolic pressure occurs when your heart contracts. Diastolic pressure occurs when your heart relaxes and fills with blood. Blood pressure is measured using millimeters of mercury (mmHg), a standardized measurement of pressure. The higher your systolic or diastolic blood pressure – and the longer it stays high – the greater the potential damage to your blood vessels. Always consult with your health care provider before making changes to your blood pressure management plan.

It is considered low blood pressure when the systolic blood pressure (the top number) is below 90 mmHg and/or the diastolic blood pressure (the bottom number) is below 60 mmHg.
Some people have low blood pressure but it doesn’t cause any symptoms and it isn’t a cause for concern. In fact, most doctors don’t consider low blood pressure a problem if there are no symptoms and no other warning signs.
Other people can have low blood pressure due to an underlying medical condition or medication which must be treated and addressed.
If you have low blood pressure or are experiencing symptoms of low blood pressure, talk to your health care provider.
What can cause low blood pressure?
There are many causes of low blood pressure. Some people naturally have lower blood pressure and it isn’t a cause for concern if they don’t have symptoms.
In other cases, low blood pressure is caused by something that needs to be treated. Some of the causes of low blood pressure include:
  • Dehydration
  • Medication side effects
  • Heart disease
  • Pregnancy
  • Blood loss
  • Severe infection (septicemia)
  • Severe allergy (anaphylaxis)
  • Endocrine problems
  • Nutritional deficiencies
These causes can range from easily treatable conditions to medical emergencies in the case of severe infection or allergy. Severely low blood pressure can deprive the brain and body of oxygen and lead to organ damage.
If you have low blood pressure, talk to your healthcare provider to determine if it’s cause for concern and needs to be treated.
What are the symptoms of low blood pressure?
Symptoms of low blood pressure to look out for are:
  • Dizziness / light headedness
  • Weakness
  • Loss of concentration / focus
  • Fatigue
  • Blurred or loss of vision
  • Nausea
  • Fainting

If you’re experiencing these symptoms, talk to your healthcare practitioner.

We talk a lot about the top number when it comes to blood pressure, but the bottom number is important as well. The top number (systolic blood pressure) refers to the blood pressure when the heart is contracting. The bottom number (diastolic blood pressure) refers to the blood pressure when the heart is relaxing, which is why this number is typically lower than the top. The target for the lower number is below 80, however, blood pressure targets can depend on your age and other factors so speak to your doctor to determine what your blood pressure targets should be. Low diastolic pressure can be a concern if it is associated with dizziness or lightheadedness. The diastolic number can drop with certain medications, dehydration and with stiffening of arteries as we age. Speak to your doctor if you have concerns about your diastolic blood pressure.

According to Hypertension Canada, some people have higher blood pressure at the doctor’s office, yet normal blood pressure otherwise, so they do not have hypertension at all. It is called white coat hypertension or syndrome, referring to the white lab coats worn by some health care professionals and can be ruled out with home blood pressure monitoring.

Co-administration with Medications

Consult with your primary health care provider before adding PreCardix® along-side other medications or supplements. Do not discontinue current medication without consulting with your health care provider. PreCardix® is not a substitute for medication. Monitor blood pressure regularly.

PreCardix® was not studied in combination with other medications or supplements. Interactions are inferred based on documented interactions of common ACE inhibiting drugs. Other interactions may also occur.

  • The effect of PreCardix® on blood pressure may be augmented by other blood pressure medication or natural health products and cause low blood pressure. This effect has been well-documented with individuals combining alpha-blocking medication and ACE inhibitors after the first dose. Monitor for this potential effect.
  • PreCardix® bioactive marine peptides did not increase potassium levels in the clinical trial. However, due to the ACE inhibiting action, potassium levels should be monitored frequently, particularly with agents that increase serum potassium, such as potassium-sparing diuretics, potassium supplements, and potassium-containing salts.
  • A possible causal relationship between ACE inhibitor treatments and allopurinol (a pharmaceutical treatment for gout) may lead to hypersensitivity. PreCardix® should be used cautiously with allopurinol until further research establishes safety.
  • The use of NSAIDs (such as Ibuprofen) may reduce the effect of ACE inhibiting medication. Monitor blood pressure regularly if you are taking NSAIDs with PreCardix®.
  • Intravenous iron infusion should be administered cautiously in individuals using PreCardix®. ACE inhibitors may augment the systemic effects of IV iron. Oral iron supplementation is not a concern.
  • Individuals taking lithium should have lithium levels monitored frequently. ACE inhibitors may decrease renal elimination of lithium, leading to lithium toxicity (CNS symptoms, ECG changes, renal failure). PreCardix® was not studied along-side lithium medication

Share the PreCardix® product monograph with your health care provider who can advise you on drug interactions, contra-indications and other factors related to your health to help determine if PreCardix® is appropriate for you.

PreCardix® clinical trials were conducted on a healthy population who were not on any type of medication and had no other health conditions other than mild-moderately elevated blood pressure. Individuals with pre-existing medical conditions should speak with their health care provider before introducing PreCardix® to ensure safety and wellbeing. Similarly, individuals who are on any medications or supplements should be closely monitored by their primary health care provider before introducing PreCardix®.

Share the PreCardix® product monograph with your health care provider who can advise you on drug interactions, contra-indications and other factors related to your health to help determine if PreCardix® is appropriate for you.

PreCardix® has not been studied in individuals with a history of angioedema related to the previous use of ACE inhibitors and should be avoided in this population. PreCardix® has not been studied in individuals who have renal artery stenosis and should be avoided in this population based on the known contraindication with pharmaceutical ACE inhibitor medication. Individuals who have an allergy to shellfish should not take PreCardix®.

For additional information please refer to Product Information and Directions.

Always consult with your health care provider before making changes to your blood pressure management plan. PreCardix® does not treat, cure or prevent medical conditions.  Measure and monitor blood pressure regularly. Know the signs of heart attack and stroke. Do not take PreCardix® if you are pregnant, breastfeeding, have renal artery stenosis, history of angioneurotic edema or shellfish allergy.

Dosing and Administration

In our trials and testing, we have conducted extensive research on the safety and efficacy of PreCardix®. While our findings from a toxicology study indicate that doses up to 100 times the recommended daily dose did not cause hypotension, other overdose reactions or safety issues, the dose used in clinical trials was 2 tablets together daily, therefore making this the recommended daily dose.

It is best to take PreCardix® away from food, medications, supplements as well as caffeinated drinks, as these may interfere with the absorption of the product and reduce its positive impact on blood pressure health. Since caffeine can be a factor in elevated blood pressure, it is recommended to measure your blood pressure before and after consuming caffeine to determine potential effects on blood pressure levels. For long-term monitoring, blood pressure should be measured before drinking caffeinated drinks. For additional questions, please contact us at support@precardix.ca.

Follow the directions on the package. The recommended dosage is to take two (2) tablets  (1200mg) together once daily, preferably away from food. Continue to take daily to maintain results. Blood pressure may rise to pre-treatment levels if it is discontinued.

In clinical trials, participants took two tablets of PreCardix® together, in between meals and in the morning.

89% of participants experienced a significant effect on their blood pressure within 8 weeks. This is the reason we advise taking two tablets of PreCardix® (1200mg) together once daily, preferably away from food. Allow 8 weeks (2 packs) to achieve results. Continue to take daily to maintain results.

The reason that we advise to take PreCardix® before noon is the simple fact that in our clinical trial, two tablets of PreCardix® were taken every morning. We recommend taking PreCardix® daily before noon, a few hours before or after medications, and preferably away from natural health products or food to maximize absorption of the bioactive marine peptides. This was the dosing strategy used in the clinical study that found a significant effect on blood pressure health in 89% of trial participants, in 8 weeks or less.

To learn more about what to expect when you start taking PreCardix®, and for best results, please visit us here.

Step 1: Record baseline blood pressure using the PreCardix® app or a blood pressure log. Baseline blood pressure is your blood pressure before starting PreCardix. You can learn how to find your baseline blood pressure here.

Step 2: Take PreCardix as directed.

Step 3: Record blood pressure at the end of each week.

Step 4: Compare week eight blood pressure to baseline blood pressure.

Step 5. Review your results with your health care provider.

Every 2mmHg improvement in blood pressure has a positive effect on outcomes.

To learn more about what to expect when you start taking PreCardix®, and for best results, please visit us here.

If you are just starting to measure your blood pressure at home, it is important to calculate your baseline blood pressure. Measure your blood pressure (before starting PreCardix® twice in the morning and twice in the evening for 7 days in a row. Discard the first day of readings and average the last 6 days. Record in this printable (PDF) or the PreCardix® blood pressure app.  Share this information with your health care provider to discuss your baseline blood pressure readings and how to best support your blood pressure health.

Measure your weekly blood pressure once a week, twice each morning and each evening every day for eight weeks. Record your blood pressure using the PreCardix® blood pressure App or a blood pressure log.

Calculate your average blood pressure using the PreCardix® blood pressure App or a blood pressure log. Compare your baseline blood pressure to your blood pressure after eight weeks. Every 2mmHg improvement in blood pressure has a positive effect on outcomes.

Despite the size of the tablets, they have a smooth coating that makes them easy to swallow. However, if you are unable to swallow them whole, we recommend breaking them in half. When breaking the coating, the ‘marine flavor’ will likely be noticeable, and so we would not recommend crushing the tablets or dissolving them in water, as moisture is not ideal for the ingredient.
Take two PreCardix® tablets together, 1 time per day. Take a few hours (2-3 hours) before or after taking other medications or natural health products. Take between meals, before noon.

When taking PreCardix® as directed, you may see an improvement in blood pressure within 2-8 weeks. You should take PreCardix® for a minimum of 8 weeks before determining if it works for you. In the clinical trial, 31% of participants experienced a significant effect on their blood pressure compared to baseline after just 2 weeks, while 89% of participants experienced a significant effect in blood pressure compared to baseline after 8 weeks.

Continue to take PreCardix® daily to maintain results.

PreCardix® can be taken to support cardiovascular health. Maintaining healthy blood pressure is especially important if there is a family history of stroke, heart attack or high blood pressure. You can learn more about how PreCardix® can play a crucial role in the management of blood pressure here.

Yes, the peptides in PreCardix® should be considered as part of your daily protein consumption, however they only contain a very small amount of protein. Most official nutrition organizations recommend a modest protein intake of around 0.8 grams of protein per kilogram of body weight. The daily dosage of protein found in PreCardix® is 1.2 grams. If your body weight is 70 kg this means you still need an additional daily protein intake of 54.8 grams.

PreCardix® has been studied in an adult population who are experiencing mild-moderately elevated blood pressure. PreCardix® has not been studied in patients with blood sugar regulation concerns and we have no data to suggest it impacts blood sugar levels.

If you have diabetes and are considering PreCardix® for your blood pressure health, consult with your health care provider before initiating PreCardix®. Share the PreCardix® product monograph with your health care provider who can advise you on drug interactions, contra-indications and other factors related to your health to help determine if PreCardix® is appropriate for you, as well as monitor you closely and effectively.

PreCardix® has not been studied on cholesterol and has not been found to impact cholesterol levels.

PreCardix® tablets contain a unique refined shrimp peptide concentrate (Marealis RSPC). This unique peptide concentrate is derived from the proteins of fresh, cold water Arctic shrimp shells (Pandalus Borealis) through a controlled enzymatic hydrolysis process. Enzymatic hydrolysis breaks down larger protein chains into smaller, peptide chains. These peptide chains are further refined into Marealis RSPC through a proprietary process resulting in a clinically proven bioactive peptide with an ACE inhibiting action.

The amount of active ingredient per recommended daily dosage of 2 tablets is 1,200 mg of shrimp peptide concentrate. In the earlier stages of our research and clinical studies, an important finding was that 1,200 mg of shrimp peptide concentrate is needed daily for it to have a significant effect on blood pressure health. In further clinical studies, 2 tablets of PreCardix® were taken simultaneously daily and 89% of clinical trial participants experienced a significant effect on their blood pressure health within 8 weeks (about 2 months) or less. Therefore, it is important that 2 tablets of PreCardix® are taken together every day.

PreCardix® did not impact serum potassium or kidney function in clinical research. Considering PreCardix® bioactive marine peptides have a natural ACE-inhibiting action, monitoring these parameters along with blood sugars at baseline and throughout treatment may be warranted at your health care provider’s discretion.

You can also learn more about our blood pressure tracking App here.

The PreCardix® box contains 60 tablets. The dosage is 2 tablets per day, therefore one box lasts 30 days.

PreCardix® should be stored at room temperature. It does not need to be refrigerated.

It is important that 2 tablets of PreCardix® are taken together every day.  The amount of active ingredient per recommended daily dosage of 2 tablets is 1,200 mg of shrimp peptide concentrate. In the earlier stages of our research and clinical studies, an important finding was that 1,200 mg of shrimp peptide concentrate is needed daily for it to have a significant effect on blood pressure health. In further clinical studies, 2 tablets of PreCardix® were taken simultaneously daily and 89% of clinical trial participants experienced a significant effect on their blood pressure health within 8 weeks (about 2 months) or less. Therefore, it is important that 2 tablets of PreCardix® are taken together every day.

Skipping a day when taking PreCardix® is not recommended. It advised to adhere to the daily recommended dose to maintain the desired results. The recommended dosage is to take two (2) tablets (1200mg) together once daily, preferably away from food.

Consistency in taking PreCardix® is essential, as discontinuing use may lead to a rise in blood pressure, potentially returning it to pre-treatment levels. Therefore, to achieve and maintain results, it’s encouraged to follow the provided dosing instructions and take PreCardix® consistently each day.

Yes, I want healthy blood pressure in eight weeks!*

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*Based on results from clinical trial, individual results may vary [International Journal of Hypertension, Article 2345042]

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